School of Veterinary Medicine

Comparative Pathology Lab

Anatomic Pathology

Anatomic Pathology & Histopathology Processing

At CPL, we often receive inquiries about histopathology interpretation of sectioned and stained tissue slides. Principal investigators and researchers who need to quantify or characterize the effects of experimental procedures have used our services extensively. The staff pathologists at CPL have a long-standing relationship with the scientific community through scientific paper collaborations also.

The Comparative Pathology Laboratory regularly receives submissions of preserved or fresh-frozen tissues for histopathology procedures. Pathology activities also include gross necropsy evaluations of experimental and control animals. As our skilled necropsy staff performs target tissue examination and harvesting, areas of specific interest are isolated. Histopathology evaluations of these tissues are accomplished through fixation or flash freezing of trimmed tissues. These harvested tissues are then subjected to vacuum infiltration processing, paraffin embedding, thin sectioning and slide mounting. Routinely, these slides are stained with hematoxylin & eosin (H & E) for our staff pathologists’ interpretations. Arrangements for immunohistochemical and other special stains can be easily made.

Please see our Services Listing for the various types of pathology collections available to complement the specific demands of your protocols. The staff pathologists can custom tailor a group of services to help showcase your project’s focus. We can additionally generate high resolution photographic images of microscopic and gross tissue findings to support your studies.

Addtional services include mutant mouse strain phenotyping, diagnostic gross necropsy examinations with tissue characterizations and recording of organ weights and specific orientation tissue collections, such as “gut-rolls”, brown fat, eye, brain, reproductive organ isolations. Photomicroscopic analysis of digital tissue images using Olympus CellSens Dimension “Count & Measure” software.

The Comparative Pathology Laboratory regularly provides services to most of the University of California (UC) campuses and has close ties to many of their rodent biology programs. Much of our workload also comes from commercial biotechnology companies and outside academic institutions. Some of the organizations we deal with on the UC Davis campus include:

  • UC Davis Medical Center research labs (at UCDHS)
  • UC Davis Center for Comparative Medicine (CCM) and Mouse Biology Program (MBP)
  • UC Davis Teaching And Research Animal Care Services (TRACS)
  • Campus Veterinary Services (CVS)
  • National Mouse Metabolic Phenotyping Center (MMPC)

CPL often provides services to scientists developing custom bred rodent strains for use in stem cell and pharmaceutical development.

The Laboratory has been involved for many years with researchers investigating drug transport, dosage efficacy and drug toxicity studies. We have provided service to increasing numbers of projects requiring mouse model phenotyping, due to advances made in transgenic technologies.

The Comparative Pathology Laboratory has staff pathologists available to consult with you about your particular project.  They can consult with you about your project focus and define necropsy activities, as well as ensure that histopathology evaluations target the anatomic areas of interest.  Please call to arrange a consultation with a staff pathologist.

Anatomic Pathology Necropsy Room